Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance
Insulin resistance is a major risk factor for type 2 diabetes mellitus. The protein encoded by the sirtuin 1 (Sirt1) gene, which is a mouse homolog of yeast Sir2, is implicated in the regulation of glucose metabolism and insulin sensitivity; however, the underlying mechanism remains elusive. Here, u...
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| Hlavní autoři: | , , , , , |
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| Médium: | Artigo |
| Jazyk: | angličtina |
| Vydáno: |
2011
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| On-line přístup: | https://doi.org/10.1172/jci46243 http://www.jci.org/articles/view/46243/files/pdf |
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