Shank3 Deficiency Induces NMDA Receptor Hypofunction via an Actin-Dependent Mechanism
Shank3, which encodes a scaffolding protein at glutamatergic synapses, is a genetic risk factor for autism. In this study, we examined the impact of Shank3 deficiency on the NMDA-type glutamate receptor, a key player in cognition and mental illnesses. We found that knockdown of Shank3 with a small i...
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2013
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| Online Access: | https://doi.org/10.1523/jneurosci.1175-13.2013 https://www.jneurosci.org/content/jneuro/33/40/15767.full.pdf |
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