Blocking the apolipoprotein E/Amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology

Inheritance of the apolipoprotein E4 (apoE4) genotype has been identified as the major genetic risk factor for late-onset Alzheimer's disease (AD). Studies have shown that the binding between apoE and amyloid-β (Aβ) peptides occurs at residues 244-272 of apoE and residues 12-28 of Aβ. ApoE4 has...

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Main Authors: Shan Liu, Ariel Breitbart, Yanjie Sun, Pankaj Mehta, Allal Boutajangout, Henrieta Scholtzova, Thomas Wısnıewskı
格式: Artigo
语言:英语
出版: 2013
在线阅读:https://doi.org/10.1111/jnc.12484
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