Blocking the apolipoprotein E/Amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology

Blocking the apolipoprotein E/Amyloid β interaction in triple transgenic mice ameliorates Alzheimer's disease related amyloid β and tau pathology

Inheritance of the apolipoprotein E4 (apoE4) genotype has been identified as the major genetic risk factor for late-onset Alzheimer's disease (AD). Studies have shown that the binding between apoE and amyloid-β (Aβ) peptides occurs at residues 244-272 of apoE and residues 12-28 of Aβ. ApoE4 has...

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Bibliografiska uppgifter
Huvudupphovsmän:	Shan Liu, Ariel Breitbart, Yanjie Sun, Pankaj Mehta, Allal Boutajangout, Henrieta Scholtzova, Thomas Wısnıewskı
Materialtyp:	Artigo
Språk:	engelska
Publicerad:	2013
Länkar:	https://doi.org/10.1111/jnc.12484
Taggar:	Lägg till en tagg Inga taggar, Lägg till första taggen!

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