Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors.
Sodium-dependent uptake of bile acids across the hepatic basolateral membrane is rapidly and profoundly diminished during sepsis, thus contributing to the pathogenesis of sepsis-associated cholestasis. This effect is mediated by endotoxin or effector cytokines, which reduce expression of several hep...
Enregistré dans:
| Auteurs principaux: | , , , , |
|---|---|
| Format: | Artigo |
| Langue: | anglais |
| Publié: |
1998
|
| Accès en ligne: | https://doi.org/10.1172/jci1680 http://www.jci.org/articles/view/1680/files/pdf |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|