Endotoxin downregulates rat hepatic ntcp gene expression via decreased activity of critical transcription factors.
Sodium-dependent uptake of bile acids across the hepatic basolateral membrane is rapidly and profoundly diminished during sepsis, thus contributing to the pathogenesis of sepsis-associated cholestasis. This effect is mediated by endotoxin or effector cytokines, which reduce expression of several hep...
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| Main Authors: | , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
1998
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| Online Access: | https://doi.org/10.1172/jci1680 http://www.jci.org/articles/view/1680/files/pdf |
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