A defect in the structure of type I procollagen in a patient who had osteogenesis imperfecta: excess mannose in the COOH-terminal propeptide.

Fibroblasts from normal human subjects and from a patient who had osteogenesis imperfecta were incubated with [3H]mannose, and types I and III procollagens were isolated from the culture medium. The type I procollagen from the patient's fibroblasts contained 2-3 time more [3H]mannose than the t...

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Autors principals: Leena Peltonen, Aarno Palotie, Darwin J. Prockop
Format: Artigo
Idioma:anglès
Publicat: 1980
Accés en línia:https://doi.org/10.1073/pnas.77.10.6179
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