Free Fatty Acid-induced β-Cell Defects Are Dependent on Uncoupling Protein 2 Expression
Chronic exposure to elevated free fatty acids (lipotoxicity) induces uncoupling protein (UCP2) in the pancreatic β-cell, and therefore a causal link between UCP2 and β-cell defects associated with obesity may exist. Recently, we showed that lipid treatment in vivo and in vitro in UCP2(–/–) mice/isle...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2004
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| Online Access: | https://doi.org/10.1074/jbc.m409189200 http://www.jbc.org/article/S0021925820693929/pdf |
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