Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex

Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex

A large protein complex consisting of Atg5, Atg12 and Atg16L1 has recently been shown to be essential for the elongation of isolation membranes (also called phagophores) during mammalian autophagy. However, the precise function and regulation of the Atg12–5-16L1 complex has largely remained unknown....

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Bibliografiske detaljer
Main Authors:	Koutaro Ishibashi, Naonobu Fujita, Eiko Kanno, Hiroko Omori, Tamotsu Yoshimori, Takashi Itoh, Mitsunori Fukuda
Format:	Artigo
Sprog:	engelsk
Udgivet:	2011
Online adgang:	https://doi.org/10.4161/auto.7.12.18025 https://www.tandfonline.com/doi/pdf/10.4161/auto.7.12.18025?needAccess=true
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Lignende værker

Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12–5-16L2 complex
af: Ishibashi, Koutaro, et al.
Udgivet: (2011)

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy
af: Fujita, Naonobu, et al.
Udgivet: (2008)

The Atg16L Complex Specifies the Site of LC3 Lipidation for Membrane Biogenesis in Autophagy
af: Naonobu Fujita, et al.
Udgivet: (2008)

Golgi-resident Small GTPase Rab33B Interacts with Atg16L and Modulates Autophagosome Formation
af: Itoh, Takashi, et al.
Udgivet: (2008)

Golgi-resident Small GTPase Rab33B Interacts with Atg16L and Modulates Autophagosome Formation
af: Takashi Itoh, et al.
Udgivet: (2008)

Differential Involvement of Atg16L1 in Crohn Disease and Canonical Autophagy: ANALYSIS OF THE ORGANIZATION OF THE Atg16L1 COMPLEX IN FIBROBLASTS
af: Fujita, Naonobu, et al.
Udgivet: (2009)

Differential Involvement of Atg16L1 in Crohn Disease and Canonical Autophagy
af: Naonobu Fujita, et al.
Udgivet: (2009)

Atg16L1, an essential factor for canonical autophagy, participates in hormone secretion from PC12 cells independently of autophagic activity
af: Ishibashi, Koutaro, et al.
Udgivet: (2012)

Atg16L1, an essential factor for canonical autophagy, participates in hormone secretion from PC12 cells independently of autophagic activity
af: Koutaro Ishibashi, et al.
Udgivet: (2012)

ATG16L1 meets ATG9 in recycling endosomes
af: Claudia Puri, et al.
Udgivet: (2013)

Distinct tissue-specific roles for the disease-associated autophagy genes ATG16L2 and ATG16L1
af: Khor, Bernard, et al.
Udgivet: (2019)

The Role of WIPI2, ATG16L1 and ATG12-ATG5 in selective and nonselective autophagy
af: Daniele Campisi, et al.
Udgivet: (2025)

ULK1‐mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn's mutant
af: Alsaadi, Reham M, et al.
Udgivet: (2019)

ULK1‐mediated phosphorylation of ATG16L1 promotes xenophagy, but destabilizes the ATG16L1 Crohn's mutant
af: Reham M. Alsaadi, et al.
Udgivet: (2019)

Toward the function of mammalian ATG12–ATG5-ATG16L1 complex in autophagy and related processes
af: Lystad, Alf Håkon, et al.
Udgivet: (2019)

Toward the function of mammalian ATG12–ATG5-ATG16L1 complex in autophagy and related processes
af: Alf Håkon Lystad, et al.
Udgivet: (2019)

The V-ATPase complex regulates non-canonical Atg8-family protein lipidation through ATG16L1 recruitment
af: Timimi, Lewis, et al.
Udgivet: (2022)

Biology and trafficking of ATG9 and ATG16L1, two proteins that regulate autophagosome formation
af: Eszter Zavodszky, et al.
Udgivet: (2013)

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma
af: Hwang, Seungmin, et al.
Udgivet: (2012)

A common role for Atg16L1, Atg5, and Atg7 in small intestinal Paneth cells and Crohn’s disease
af: Cadwell, Ken, et al.
Udgivet: (2009)

A common role for Atg16L1, Atg5, and Atg7 in small intestinal Paneth cells and Crohn disease
af: Ken Cadwell, et al.
Udgivet: (2009)

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma
af: Seungmin Hwang, et al.
Udgivet: (2012)

ATG16L1 and pathogenesis of urinary tract infections
af: Wang, Caihong, et al.
Udgivet: (2012)

An alteration in ATG16L1 stability in Crohn disease
af: Lassen, Kara G, et al.
Udgivet: (2014)

Three-step docking by WIPI2, ATG16L1, and ATG3 delivers LC3 to the phagophore
af: Shanlin Rao, et al.
Udgivet: (2024)

The phenotypes of ATG9, ATG16 and ATG9/16 knock-out mutants imply autophagy-dependent and -independent functions
af: Xiong, Qiuhong, et al.
Udgivet: (2015)

Dissecting the role of the Atg12–Atg5-Atg16 complex during autophagosome formation
af: Walczak, Marta, et al.
Udgivet: (2013)

Dissecting the role of the Atg12–Atg5-Atg16 complex during autophagosome formation
af: Marta Walczak, et al.
Udgivet: (2013)

Structure of the WD40‐domain of human ATG16L1
af: Bajagic, Milica, et al.
Udgivet: (2017)

The Autophagy Gene Atg16L1 is Necessary for Endometrial Decidualization
af: Oestreich, Arin K, et al.
Udgivet: (2019)

The multifaceted functions of ATG16L1 in autophagy and related processes
af: Noor Gammoh
Udgivet: (2020)

Polymorphisms in the ATG16L1 Gene are Associated with Psoriasis Vulgaris
af: Konstantinos Douroudis, et al.
Udgivet: (2012)

ATG16L1 functions in cell homeostasis beyond autophagy
af: Daniel Hamaoui, et al.
Udgivet: (2021)

Structure of Atg5·Atg16, a Complex Essential for Autophagy
af: Minako Matsushita, et al.
Udgivet: (2006)

Crystallization of the Atg12–Atg5 conjugate bound to Atg16 by the free-interface diffusion method
af: Noda, Nobuo N., et al.
Udgivet: (2008)

Three-Axis Model for Atg Recruitment in Autophagy against Salmonella
af: Noda, Takeshi, et al.
Udgivet: (2012)

ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12–ATG5-ATG16L1 complex assembly and autophagy
af: Wible, Daric J., et al.
Udgivet: (2019)

ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12–ATG5-ATG16L1 complex assembly and autophagy
af: Daric J. Wible, et al.
Udgivet: (2019)

ATG16L2 overexpression is associated with a good prognosis in colorectal cancer
af: Tang, Jian, et al.
Udgivet: (2021)

Structural basis for membrane recruitment of ATG16L1 by WIPI2 in autophagy
af: Strong, Lisa M, et al.
Udgivet: (2021)