Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice
Epsins are endocytic adaptors with putative functions in general aspects of clathrin-mediated endocytosis as well as in the internalization of specific membrane proteins. We have now tested the role of the ubiquitously expressed epsin genes, Epn1 and Epn2, by a genetic approach in mice. While either...
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| Auteurs principaux: | , , , , , , , , , , , |
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| Format: | Artigo |
| Langue: | anglais |
| Publié: |
2009
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| Accès en ligne: | https://doi.org/10.1073/pnas.0907008106 |
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