Mutant <i> Ikzf1, Kras <sup>G12D</sup> </i> , and <i>Notch1</i> cooperate in T lineage leukemogenesis and modulate responses to targeted agents

Mutant <i> Ikzf1, Kras <sup>G12D</sup> </i> , and <i>Notch1</i> cooperate in T lineage leukemogenesis and modulate responses to targeted agents

Mice that accurately model the genetic diversity found in human cancer are valuable tools for interrogating disease mechanisms and investigating novel therapeutic strategies. We performed insertional mutagenesis with the MOL4070LTR retrovirus in Mx1-Cre, Kras G12D mice and generated a large cohort o...

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Main Authors: Monique Dail, Qing Li, Andrew S. McDaniel, Jason W.H. Wong, Keiko Akagi, Benjamin J. Huang, Hio Chung Kang, Scott C. Kogan, Kevan M. Shokat, Linda Wolff, Benjamin S. Braun, Kevin Shannon
Format: Artigo
Language:English
Published: 2010
Online Access:https://doi.org/10.1073/pnas.1001064107
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https://doi.org/10.1073/pnas.1001064107

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