A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
An intact T/E1A-binding domain (the pocket) is necessary, but not sufficient, for the retinoblastoma protein (RB) to bind to DNA-protein complexes containing E2F and for RB to induce a G1/S block. Indirect evidence suggests that the binding of RB to E2F may, in addition to inhibiting E2F transactiva...
Enregistré dans:
| Auteurs principaux: | , , |
|---|---|
| Format: | Artigo |
| Langue: | anglais |
| Publié: |
1995
|
| Accès en ligne: | https://doi.org/10.1073/pnas.92.25.11544 |
| Tags: |
Ajouter un tag
Pas de tags, Soyez le premier à ajouter un tag!
|