A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
An intact T/E1A-binding domain (the pocket) is necessary, but not sufficient, for the retinoblastoma protein (RB) to bind to DNA-protein complexes containing E2F and for RB to induce a G1/S block. Indirect evidence suggests that the binding of RB to E2F may, in addition to inhibiting E2F transactiva...
Tallennettuna:
| Päätekijät: | , , |
|---|---|
| Aineistotyyppi: | Artigo |
| Kieli: | englanti |
| Julkaistu: |
1995
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| Linkit: | https://doi.org/10.1073/pnas.92.25.11544 |
| Tagit: |
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