A potent transrepression domain in the retinoblastoma protein induces a cell cycle arrest when bound to E2F sites.
An intact T/E1A-binding domain (the pocket) is necessary, but not sufficient, for the retinoblastoma protein (RB) to bind to DNA-protein complexes containing E2F and for RB to induce a G1/S block. Indirect evidence suggests that the binding of RB to E2F may, in addition to inhibiting E2F transactiva...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
1995
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| Online Access: | https://doi.org/10.1073/pnas.92.25.11544 |
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