The Crystal Structure of BRAF in Complex with an Organoruthenium Inhibitor Reveals a Mechanism for Inhibition of an Active Form of BRAF Kinase
Substitution mutations in the BRAF serine/threonine kinase are found in a variety of human cancers. Such mutations occur in approximately 70% of human malignant melanomas, and a single hyperactivating V600E mutation is found in the activation segment of the kinase domain and accounts for more than 9...
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| Autores principales: | , , , , , , |
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| Formato: | Artigo |
| Lenguaje: | inglés |
| Publicado: |
2009
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| Acceso en línea: | https://doi.org/10.1021/bi802067u |
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