Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1–haploinsufficient osteoclast functions
Individuals with neurofibromatosis type 1 (NF1) have a high incidence of osteoporosis and osteopenia. However, understanding of the cellular and molecular basis of these sequelae is incomplete. Osteoclasts are specialized myeloid cells that are the principal bone-resorbing cells of the skeleton. We...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2006
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| Online Access: | https://doi.org/10.1172/jci29092 http://www.jci.org/articles/view/29092/files/pdf |
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