Hyperactivation of p21ras and PI3K cooperate to alter murine and human neurofibromatosis type 1–haploinsufficient osteoclast functions

Individuals with neurofibromatosis type 1 (NF1) have a high incidence of osteoporosis and osteopenia. However, understanding of the cellular and molecular basis of these sequelae is incomplete. Osteoclasts are specialized myeloid cells that are the principal bone-resorbing cells of the skeleton. We...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Feng‐Chun Yang, Shi Chen, Alexander G. Robling, Xijie Yu, Todd D. Nebesio, Jincheng Yan, Trent Morgan, Xiaohong Li, Jin Yuan, Janet M. Hock, David A. Ingram, D. Wade Clapp
Fformat: Artigo
Iaith:Saesneg
Cyhoeddwyd: 2006
Mynediad Ar-lein:https://doi.org/10.1172/jci29092
http://www.jci.org/articles/view/29092/files/pdf
Tagiau: Ychwanegu Tag
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