Genetic analysis of the Complexin trans-clamping model for cross-linking SNARE complexes in vivo

Significance Synaptic vesicle fusion at synapses is the primary mechanism by which neurons communicate. A highly conserved membrane fusion machine known as the SNARE complex mediates this process. In addition, neuronal SNARE-binding regulatory proteins have evolved to control the kinetics and speed...

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Autors principals: Richard W. Cho, Daniel Kümmel, Feng Li, Stephanie Wood Baguley, Jeff Coleman, James E. Rothman, J. Troy Littleton
Format: Artigo
Idioma:anglès
Publicat: 2014
Accés en línia:https://doi.org/10.1073/pnas.1409311111
https://www.pnas.org/content/pnas/111/28/10317.full.pdf
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