Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs

Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs

MHC class II-restricted antigen presentation plays a central role in the immune response against exogenous antigens. The association of invariant (Ii) chain with MHC class II dimers is required for proper antigen presentation to CD4 + T cells by antigen-presenting cells. MHC class II complexes first...

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Autores principales: Jacek Bania, Evelina Gatti, Hugues Lelouard, Alexandre David, Francesco Cappello, Ekkehard Weber, Voahirana Camosseto, Philippe Pierre
Formato: Artigo
Lenguaje:inglés
Publicado: 2003
Acceso en línea:https://doi.org/10.1073/pnas.1131604100
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https://doi.org/10.1073/pnas.1131604100

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