Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs

Human cathepsin S, but not cathepsin L, degrades efficiently MHC class II-associated invariant chain in nonprofessional APCs

MHC class II-restricted antigen presentation plays a central role in the immune response against exogenous antigens. The association of invariant (Ii) chain with MHC class II dimers is required for proper antigen presentation to CD4 + T cells by antigen-presenting cells. MHC class II complexes first...

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Hauptverfasser:	Jacek Bania, Evelina Gatti, Hugues Lelouard, Alexandre David, Francesco Cappello, Ekkehard Weber, Voahirana Camosseto, Philippe Pierre
Format:	Artigo
Sprache:	Englisch
Veröffentlicht:	2003
Online-Zugang:	https://doi.org/10.1073/pnas.1131604100
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

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