Neurons generated by direct conversion of fibroblasts reproduce synaptic phenotype caused by autism-associated neuroligin-3 mutation
Significance A major challenge in modeling human diseases is to replicate disease phenotypes in neurons that are differentiated from nonneuronal cells, such as pluripotent stem cells or fibroblasts. However, evidence that phenotypes observed with this approach replicate an endogenous disease phenoty...
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| Main Authors: | , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2013
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| 在線閱讀: | https://doi.org/10.1073/pnas.1316240110 |
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