PAK signaling in cancer

PAK signaling in cancer

Transformation of a normal cell to a cancer cell is caused by mutations in genes that regulate proliferation, apoptosis, and invasion. Small GTPases such as Ras, Rho, Rac and Cdc42 orchestrate many of the signals that are required for malignant transformation. The p21-activated kinases (PAKs) are ef...

Shranjeno v:

Bibliografske podrobnosti
Main Authors:	Diana Zi Ye, Jeffrey Field
Format:	Artigo
Jezik:	angleščina
Izdano:	2012
Online dostop:	https://doi.org/10.4161/cl.21882 https://www.tandfonline.com/doi/pdf/10.4161/cl.21882?needAccess=true
Oznake:	Označite Brez oznak, prvi označite!

Podobne knjige/članki

PAK signaling in cancer
od: Ye, Diana Zi, et al.
Izdano: (2012)

Pak protein kinases and their role in cancer
od: Bettina Dümmler, et al.
Izdano: (2009)

Pak protein kinases and their role in cancer
od: Dummler, Bettina, et al.
Izdano: (2009)

The Akt Proto-oncogene Links Ras to Pak and Cell Survival Signals
od: Yi Tang, et al.
Izdano: (2000)

The PAKs come of age: Celebrating 18 years of discovery
od: Field, Jeffrey, et al.
Izdano: (2012)

PAK signaling in oncogenesis
od: Poonam R. Molli, et al.
Izdano: (2009)

Pak Signaling in the Development and Progression of Cancer
od: Radu, Maria, et al.
Izdano: (2014)

PAK Signaling in Oncogenesis
od: Molli, Poonam R., et al.
Izdano: (2009)

Signals from the Ras, Rac, and Rho GTPases Converge on the Pak Protein Kinase in Rat-1 Fibroblasts
od: Tang, Yi, et al.
Izdano: (1999)

PAK signalling during the development and progression of cancer
od: Maria Radu, et al.
Izdano: (2013)

Signals from the Ras, Rac, and Rho GTPases Converge on the Pak Protein Kinase in Rat-1 Fibroblasts
od: Yi Tang, et al.
Izdano: (1999)

Functional Deficits in Pak5, Pak6 and Pak5/Pak6 Knockout Mice
od: Furnari, Melody A., et al.
Izdano: (2013)

PAK4 signaling in health and disease: defining the PAK4–CREB axis
od: So-Yoon Won, et al.
Izdano: (2019)

PAK4 signaling in health and disease: defining the PAK4–CREB axis
od: Won, So-Yoon, et al.
Izdano: (2019)

Opposing Roles for Akt1 and Akt2 in Rac/Pak Signaling and Cell Migration
od: Guo-Lei Zhou, et al.
Izdano: (2006)

p21-Activated Kinase 1 (Pak1) Phosphorylates BAD Directly at Serine 111 In Vitro and Indirectly through Raf-1 at Serine 112
od: Ye, Diana Z., et al.
Izdano: (2011)

Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs
od: Jeyanthy Eswaran, et al.
Izdano: (2007)

Crystal Structures of the p21-Activated Kinases PAK4, PAK5, and PAK6 Reveal Catalytic Domain Plasticity of Active Group II PAKs
od: Eswaran, Jeyanthy, et al.
Izdano: (2007)

Pak1 and Pak2 Mediate Tumor Cell Invasion through Distinct Signaling Mechanisms
od: Salvatore J. Coniglio, et al.
Izdano: (2008)

Pak1 and Pak2 Mediate Tumor Cell Invasion through Distinct Signaling Mechanisms
od: Coniglio, Salvatore J., et al.
Izdano: (2008)

A role for Pak protein kinases in Schwann cell transformation
od: Yi Tang, et al.
Izdano: (1998)

PAK1, PAK1Δ15, and PAK2: similarities, differences and mutual interactions
od: Grebeňová, Dana, et al.
Izdano: (2019)

Signalling to cancer cell invasion through PAK family kinases
od: Andrew Whale, et al.
Izdano: (2010)

A role for Pak protein kinases in Schwann cell transformation
od: Tang, Yi, et al.
Izdano: (1998)

PAK to the future
od: Shubha Bagrodia, et al.
Izdano: (1999)

LC-0882 targets PAK4 and inhibits PAK4-related signaling pathways to suppress the proliferation and invasion of gastric cancer cells
od: Zhang, Hong-Yan, et al.
Izdano: (2017)

Differential sensitivity of Pak5, Pak6, and Pak5/Pak6 double-knockout mice to the stimulant effects of amphetamine and exercise-induced alterations in body weight
od: Furnari, Melody A., et al.
Izdano: (2013)

GL-1196 Suppresses the Proliferation and Invasion of Gastric Cancer Cells via Targeting PAK4 and Inhibiting PAK4-Mediated Signaling Pathways
od: Zhang, Jian, et al.
Izdano: (2016)

Differential role for PAK1 and PAK4 during the invadopodia lifecycle
od: Nicholas, Nicole S., et al.
Izdano: (2017)

The significance of PAK4 in signaling and clinicopathology: A review
od: Yu, Xinbo, et al.
Izdano: (2022)

Differential expression and phosphorylation of Pak1 and Pak2 in ovarian cancer: effects on prognosis and cell invasion
od: Michelle K.Y. Siu, et al.
Izdano: (2009)

PAK family kinases
od: Zhuo-shen Zhao, et al.
Izdano: (2012)

The Mechanism of PAK Activation
od: Claire Chong, et al.
Izdano: (2001)

Targeting PAK1
od: Galina Semenova, et al.
Izdano: (2017)

Targeting PAK1
od: Semenova, Galina, et al.
Izdano: (2017)

Kinase-Deficient Pak1 Mutants Inhibit Ras Transformation of Rat-1 Fibroblasts
od: Yi Tang, et al.
Izdano: (1997)

Akt Phosphorylation of Serine 21 on Pak1 Modulates Nck Binding and Cell Migration
od: Guo-Lei Zhou, et al.
Izdano: (2003)

Expansion of BCR/ABL1 (+) cells requires PAK2 but not PAK1
od: Edlinger, Leo, et al.
Izdano: (2017)

The p21-activated Kinase PAK3 Forms Heterodimers with PAK1 in Brain Implementing Trans-regulation of PAK3 Activity
od: Combeau, Gaëlle, et al.
Izdano: (2012)

Akt Phosphorylation of Serine 21 on Pak1 Modulates Nck Binding and Cell Migration
od: Zhou, Guo-Lei, et al.
Izdano: (2003)