Ceramide synthase 4 and <i>de novo</i> production of ceramides with specific N-acyl chain lengths are involved in glucolipotoxicity-induced apoptosis of INS-1 β-cells
Pancreatic β-cell apoptosis induced by palmitate requires high glucose concentrations. Ceramides have been suggested to be important mediators of glucolipotoxicity-induced β-cell apoptosis. In INS-1 β-cells, 0.4 mM palmitate with 5 mM glucose increased the levels of dihydrosphingosine and dihydrocer...
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| Main Authors: | , , , , , , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2011
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| 在線閱讀: | https://doi.org/10.1042/bj20101386 |
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