Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations

Genome-Wide Association Study Identifies HLA-DP as a Susceptibility Gene for Pediatric Asthma in Asian Populations

Asthma is a complex phenotype influenced by genetic and environmental factors. We conducted a genome-wide association study (GWAS) with 938 Japanese pediatric asthma patients and 2,376 controls. Single-nucleotide polymorphisms (SNPs) showing strong associations (P<1×10−8) in GWAS were further gen...

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Main Authors: Emiko Noguchi, Hiromi Sakamoto, Tomomitsu Hirota, Kaori Ochiai, Yoshimasa Imoto, Masafumi Sakashita, Fumitake Kurosaka, Akira Akasawa, Shigemi Yoshihara, Noriko Kanno, Yumi Yamada, Naoki Shimojo, Yoichi Kohno, Yoichi Suzuki, Mi‐Jin Kang, Ji‐Won Kwon, Soo‐Jong Hong, Ken Inoue, Yu-ichi Goto, Fumio Yamashita, Takashi Asada, Hiroshi Hirose, Ikuo Saito, Shigeharu Fujieda, Nobuyuki Hizawa, Tohru Sakamoto, Hironori Masuko, Yusuke Nakamura, Ichiro Nomura, Mayumi Tamari, Tadao Arinami, Teruhiko Yoshida, Hirohisa Saito, Kenji Matsumoto
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Acesso em linha:https://doi.org/10.1371/journal.pgen.1002170
https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002170&type=printable
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https://doi.org/10.1371/journal.pgen.1002170
https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002170&type=printable

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