Direct binding of C1q to apoptotic cells and cell blebs induces complement activation
Deficiency of early components of the classical pathway of complement, particularly C1q, predisposes to the development of systemic lupus erythematosus. Several studies have suggested an association between the classical complement pathway and the clearance of apoptotic cells. Mice with a targeted d...
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| Main Authors: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2002
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| Acesso em linha: | https://doi.org/10.1002/1521-4141(200206)32:6<1726::aid-immu1726>3.0.co;2-r |
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| _version_ | 1838359081458335744 |
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| access_facet | Acesso Aberto |
| author | Alma J. Nauta Leendert A. Trouw Mohamed R. Daha Odette Tijsma Rienk Nieuwland Wilhelm Schwaeble Alexandre R. Gingras Alberto Mantovani Erik Hack Anja Roos |
| author_facet | Alma J. Nauta Leendert A. Trouw Mohamed R. Daha Odette Tijsma Rienk Nieuwland Wilhelm Schwaeble Alexandre R. Gingras Alberto Mantovani Erik Hack Anja Roos |
| cited_by_count_is | 317 |
| collection | OpenAlex |
| description | Deficiency of early components of the classical pathway of complement, particularly C1q, predisposes to the development of systemic lupus erythematosus. Several studies have suggested an association between the classical complement pathway and the clearance of apoptotic cells. Mice with a targeted deletion of the C1q gene develop a lupus-like renal disease, which is associated with the presence of multiple apoptotic bodies in the kidney. In the present study we demonstrate that highly purified C1q binds to apoptotic cells and isolated blebs derived from these apoptotic cells. Binding of C1q to apoptotic cells occurs via the globular heads of C1q and induces activation of the classical complement pathway, as shown by the deposition of C4 and C3 on the surface of these cells and on cell-derived blebs. In addition, for the first time, we demonstrate that surface-bound C1q is present on a subpopulation of microparticles isolated from human plasma. Taken together, these observations demonstrate that C1q binds directly to apoptotic cells and blebs derived therefrom and support a role for C1q, possibly in concert with C4 and C3, in the clearance of apoptotic cells and blebs by the phagocytic system. |
| format | Artigo |
| frbr_group_id_str | doi-10.1002/1521-4141(200206)32:6<1726::aid-immu1726>3.0.co;2-r |
| id | openalex-W2011709265 |
| institution | Leiden University Medical Center |
| issn_str | 0014-2980 |
| issue_str | 6 |
| journal_title_str | European Journal of Immunology |
| language | eng |
| publishDate | 2002 |
| publisher_str | Wiley |
| spellingShingle | Direct binding of C1q to apoptotic cells and cell blebs induces complement activation Alma J. Nauta Leendert A. Trouw Mohamed R. Daha Odette Tijsma Rienk Nieuwland Wilhelm Schwaeble Alexandre R. Gingras Alberto Mantovani Erik Hack Anja Roos |
| title | Direct binding of C1q to apoptotic cells and cell blebs induces complement activation |
| title_full | Direct binding of C1q to apoptotic cells and cell blebs induces complement activation |
| title_fullStr | Direct binding of C1q to apoptotic cells and cell blebs induces complement activation |
| title_full_unstemmed | Direct binding of C1q to apoptotic cells and cell blebs induces complement activation |
| title_short | Direct binding of C1q to apoptotic cells and cell blebs induces complement activation |
| topic_facet | Classical complement pathway Complement C1q Apoptosis Biology Complement system Cell biology Alternative complement pathway Cell Systemic lupus erythematosus Immunology Immune system Disease Biochemistry Medicine Pathology |
| url | https://doi.org/10.1002/1521-4141(200206)32:6<1726::aid-immu1726>3.0.co;2-r |
| volume_str | 32 |