Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells

Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells

This report describes an unbiased method for systematically determining gene function in mammalian cells. A total of 20,704 predicted human full-length cDNAs were tested for induction of the IL-8 promoter. A number of genes, including those for cytokines, receptors, adapters, kinases, and transcript...

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Main Authors: Vadim Iourgenko, Wenjun Zhang, Craig Mickanin, Ira Daly, Can Jiang, J. Mark Hexham, Anthony P. Orth, Loren Miraglia, Jodi Meltzer, Dan Garza, Gung‐Wei Chirn, Elizabeth McWhinnie, Dalia Cohen, Joanne Skelton, Robert Terry, Yang Yu, Dale L. Bodian, Frank P. Buxton, Jian Zhu, Chuanzheng Song, Mark Labow
Format: Artigo
Sprog:engelsk
Udgivet: 2003
Online adgang:https://doi.org/10.1073/pnas.1932773100
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https://doi.org/10.1073/pnas.1932773100

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