Mutant androgen receptor detected in an advanced-stage prostatic carcinoma is activated by adrenal androgens and progesterone.
Structural changes of the androgen receptor (AR) may contribute to the development of resistance to endocrine therapy in prostatic carcinoma. We have isolated AR cDNA fragments from seven tumor specimens derived from patients with advanced metastatic prostatic tumors. In one specimen obtained from a...
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| Main Authors: | , , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
1993
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| Online Access: | https://doi.org/10.1210/mend.7.12.8145761 https://academic.oup.com/mend/article-pdf/7/12/1541/9079613/mend1541.pdf |
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