Cardiac Glycosides Induce Cell Death in Human Cells by Inhibiting General Protein Synthesis

Background Cardiac glycosides are Na+/K+-pump inhibitors widely used to treat heart failure. They are also highly cytotoxic, and studies have suggested specific anti-tumor activity leading to current clinical trials in cancer patients. However, a definitive demonstration of this putative anti-cancer...

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Hlavní autoři: Andrea Perné, Markus K. Muellner, Magdalena Steinrueck, Nils Craig-Mueller, Julia Mayerhofer, Ilse Schwarzinger, Mathew A. Sloane, Iris Z. Uras, Gregor Hoermann, Sebastian Nijman, Matthias Mayerhofer
Médium: Artigo
Jazyk:angličtina
Vydáno: 2009
On-line přístup:https://doi.org/10.1371/journal.pone.0008292
https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0008292&type=printable
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