Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues

Aberrant DNA methylation often occurs in colorectal cancer (CRC). In our study we applied a genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially methylated regions (DMRs) in 24 tumors and matched normal colon samples. In total, 2687 frequently hypermethylated and 4...

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Hlavní autoři: Femke Simmer, Arie B. Brinkman, Yassen Assenov, Filomena Matarese, Anita Kaan, Lina Sabatino, Alberto Villanueva, Dori Huertas, Manel Esteller, Thomas Lengauer, Christoph Bock, Vittorio Colantuoni, Lucia Altucci, Hendrik G. Stunnenberg
Médium: Artigo
Jazyk:angličtina
Vydáno: 2012
On-line přístup:https://doi.org/10.4161/epi.22562
https://www.tandfonline.com/doi/pdf/10.4161/epi.22562?needAccess=true
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