Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues

Comparative genome-wide DNA methylation analysis of colorectal tumor and matched normal tissues

Aberrant DNA methylation often occurs in colorectal cancer (CRC). In our study we applied a genome-wide DNA methylation analysis approach, MethylCap-seq, to map the differentially methylated regions (DMRs) in 24 tumors and matched normal colon samples. In total, 2687 frequently hypermethylated and 4...

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Main Authors: Femke Simmer, Arie B. Brinkman, Yassen Assenov, Filomena Matarese, Anita Kaan, Lina Sabatino, Alberto Villanueva, Dori Huertas, Manel Esteller, Thomas Lengauer, Christoph Bock, Vittorio Colantuoni, Lucia Altucci, Hendrik G. Stunnenberg
Format: Artigo
Language:English
Published: 2012
Online Access:https://doi.org/10.4161/epi.22562
https://www.tandfonline.com/doi/pdf/10.4161/epi.22562?needAccess=true
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https://doi.org/10.4161/epi.22562
https://www.tandfonline.com/doi/pdf/10.4161/epi.22562?needAccess=true

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