Inhibitors of Amyloid Toxicity Based on β-sheet Packing of Aβ40 and Aβ42

Amyloid fibrils associated with Alzheimer's disease and a wide range of other neurodegenerative diseases have a cross β-sheet structure, where main chain hydrogen bonding occurs between β-strands in the direction of the fibril axis. The surface of the β-sheet has pronounced ridges and grooves w...

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Autori principali: Takeshi Sato, Pascal Kienlen‐Campard, Mahiuddin Ahmed, Wei Liu, Huilin Li, James I. Elliott, Saburo Aimoto, Stefan N. Constantinescu, Jean‐Noël Octave, Steven O. Smith
Natura: Artigo
Lingua:inglese
Pubblicazione: 2006
Accesso online:https://doi.org/10.1021/bi052485f
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