On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies

On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies

Abstract Background Genome-wide association studies (GWAS) with metabolic traits and metabolome-wide association studies (MWAS) with traits of biomedical relevance are powerful tools to identify the contribution of genetic, environmental and lifestyle factors to the etiology of complex diseases. Hyp...

Бүрэн тодорхойлолт

-д хадгалсан:

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Ann-Kristin Petersen, Jan Krumsiek, Brigitte Wägele, Fabian J. Theis, H.‐Erich Wichmann, Christian Gieger, Karsten Suhre
Формат:	Artigo
Хэл сонгох:	англи
Хэвлэсэн:	2012
Онлайн хандалт:	https://doi.org/10.1186/1471-2105-13-120 https://bmcbioinformatics.biomedcentral.com/counter/pdf/10.1186/1471-2105-13-120
Шошгууд:	Шошго нэмэх Шошго байхгүй, Энэхүү баримтыг шошголох эхний хүн болох!

Ижил төстэй зүйлс

On the hypothesis-free testing of metabolite ratios in genome-wide and metabolome-wide association studies
-н: Petersen, Ann-Kristin, зэрэг
Хэвлэсэн: (2012)

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum
-н: Gieger, Christian, зэрэг
Хэвлэсэн: (2008)

Genetics Meets Metabolomics: A Genome-Wide Association Study of Metabolite Profiles in Human Serum
-н: Christian Gieger, зэрэг
Хэвлэсэн: (2008)

Body Fat Free Mass Is Associated with the Serum Metabolite Profile in a Population-Based Study
-н: Jourdan, Carolin, зэрэг
Хэвлэсэн: (2012)

Body Fat Free Mass Is Associated with the Serum Metabolite Profile in a Population-Based Study
-н: Carolin Jourdan, зэрэг
Хэвлэсэн: (2012)

Mining the Unknown: A Systems Approach to Metabolite Identification Combining Genetic and Metabolic Information
-н: Jan Krumsiek, зэрэг
Хэвлэсэн: (2012)

Mining the Unknown: A Systems Approach to Metabolite Identification Combining Genetic and Metabolic Information
-н: Krumsiek, Jan, зэрэг
Хэвлэсэн: (2012)

Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data
-н: Krumsiek, Jan, зэрэг
Хэвлэсэн: (2011)

Gaussian graphical modeling reconstructs pathway reactions from high-throughput metabolomics data
-н: Jan Krumsiek, зэрэг
Хэвлэсэн: (2011)

Novel genetic associations with serum level metabolites identified by phenotype set enrichment analyses
-н: Ried, Janina S., зэрэг
Хэвлэсэн: (2014)

MassTRIX Reloaded: Combined Analysis and Visualization of Transcriptome and Metabolome Data
-н: Wägele, Brigitte, зэрэг
Хэвлэсэн: (2012)

MassTRIX Reloaded: Combined Analysis and Visualization of Transcriptome and Metabolome Data
-н: Brigitte Wägele, зэрэг
Хэвлэсэн: (2012)

metaP-Server: A Web-Based Metabolomics Data Analysis Tool
-н: Kastenmüller, Gabi, зэрэг
Хэвлэсэн: (2011)

<i>meta</i>P‐<i>Server</i>: A Web‐Based Metabolomics Data Analysis Tool
-н: Gabi Kastenmüller, зэрэг
Хэвлэсэн: (2010)

Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits
-н: Petersen, Ann-Kristin, зэрэг
Хэвлэсэн: (2014)

Epigenetics meets metabolomics: an epigenome-wide association study with blood serum metabolic traits
-н: Ann-Kristin Petersen, зэрэг
Хэвлэсэн: (2013)

The Human Blood Metabolome-Transcriptome Interface
-н: Bartel, Jörg, зэрэг
Хэвлэсэн: (2015)

The Human Blood Metabolome-Transcriptome Interface
-н: Jörg Bartel, зэрэг
Хэвлэсэн: (2015)

Computational approaches for systems metabolomics
-н: Jan Krumsiek, зэрэг
Хэвлэсэн: (2016)

A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population
-н: Sekula, Peggy, зэрэг
Хэвлэсэн: (2016)

A Metabolome-Wide Association Study of Kidney Function and Disease in the General Population
-н: Peggy Sekula, зэрэг
Хэвлэсэн: (2015)

Metabolite profiling reveals new insights into the regulation of serum urate in humans
-н: Albrecht, Eva, зэрэг
Хэвлэсэн: (2013)

Metabolite profiling reveals new insights into the regulation of serum urate in humans
-н: Eva Albrecht, зэрэг
Хэвлэсэн: (2013)

Ratios of Acetaminophen Metabolites Identify New Loci of Pharmacogenetic Relevance in a Genome-Wide Association Study
-н: Thareja, Gaurav, зэрэг
Хэвлэсэн: (2022)

Statistical methods for the analysis of high-throughput metabolomics data
-н: Bartel, Jörg, зэрэг
Хэвлэсэн: (2013)

STATISTICAL METHODS FOR THE ANALYSIS OF HIGH-THROUGHPUT METABOLOMICS DATA
-н: Jörg Bartel, зэрэг
Хэвлэсэн: (2013)

Effect of genome-wide simultaneous hypotheses tests on the discovery rate
-н: Eyheramendy, Susana, зэрэг
Хэвлэсэн: (2011)

Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies
-н: Kieu Trinh, зэрэг
Хэвлэсэн: (2018)

Gender-specific pathway differences in the human serum metabolome
-н: Jan Krumsiek, зэрэг
Хэвлэсэн: (2015)

Tissue-wide metabolomics reveals wide impact of gut microbiota on mice metabolite composition
-н: Iman Zarei, зэрэг
Хэвлэсэн: (2022)

Genome-Wide Association Studies: hypothesis-“free” or “engaged”?
-н: Kitsios, Georgios, зэрэг
Хэвлэсэн: (2009)

Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies
-н: Do, Kieu Trinh, зэрэг
Хэвлэсэн: (2018)

On the potential of models for location and scale for genome-wide DNA methylation data
-н: Wahl, Simone, зэрэг
Хэвлэсэн: (2014)

A genome-wide perspective of genetic variation in human metabolism
-н: Thomas Illig, зэрэг
Хэвлэсэн: (2009)

MoDentify: phenotype-driven module identification in metabolomics networks at different resolutions
-н: Do, Kieu Trinh, зэрэг
Хэвлэсэн: (2019)

Associations between thyroid hormones and serum metabolite profiles in an euthyroid population
-н: Jourdan, Carolin, зэрэг
Хэвлэсэн: (2013)

Metabolomics reveals effects of maternal smoking on endogenous metabolites from lipid metabolism in cord blood of newborns
-н: Rolle-Kampczyk, Ulrike E., зэрэг
Хэвлэсэн: (2016)

Widely targeted metabolomics reveals differences in metabolites of Paeonia lactiflora cultivars
-н: Y. Li, зэрэг
Хэвлэсэн: (2024)

Variational autoencoders learn transferrable representations of metabolomics data
-н: Gomari, Daniel P., зэрэг
Хэвлэсэн: (2022)

A metabolome-wide association study in the general population reveals decreased levels of serum laurylcarnitine in people with depression
-н: Zacharias, Helena U., зэрэг
Хэвлэсэн: (2021)