Generation of Nicotinic Acid Adenine Dinucleotide Phosphate and Cyclic ADP-Ribose by Glucagon-Like Peptide-1 Evokes Ca2+ Signal That Is Essential for Insulin Secretion in Mouse Pancreatic Islets
Glucagon-like peptide-1 (GLP-1) increases intracellular Ca(2+) concentrations ([Ca(2+)](i)), resulting in insulin secretion from pancreatic beta-cells. The molecular mechanism(s) of the GLP-1-mediated regulation of [Ca(2+)](i) was investigated.GLP-1-induced changes in [Ca(2+)](i) were measured in be...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2008
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| 在線閱讀: | https://doi.org/10.2337/db07-0443 |
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