Dual Roles of Tight Junction-associated Protein, Zonula Occludens-1, in Sphingosine 1-Phosphate-mediated Endothelial Chemotaxis and Barrier Integrity
In this report, sphingosine-1-phosphate (S1P), a serum-borne bioactive lipid, is shown to activate tight-junction-associated protein Zonula Occludens-1 (ZO-1), which in turn plays a critical role in regulating endothelial chemotaxis and barrier integrity. After S1P stimulation, ZO-1 was redistribute...
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| Main Authors: | , , , , , , , |
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| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2006
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| 在线阅读: | https://doi.org/10.1074/jbc.m604310200 http://www.jbc.org/article/S0021925819340128/pdf |
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