Sensitized Detection of Inhibitory Fragments and Iterative Development of Non‐Peptidic Protease Inhibitors by Dynamic Ligation Screening
A potential anti-SARS drug has been developed by dynamic ligation screening (DLS), by which nucleophilic fragments are directed to the protein's active site by reversible reaction with an aldehyde inhibitor. Their inhibitory effect is detected by competition with a fluorogenic enzyme substrate....
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| Main Authors: | , , , , , , |
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| Format: | Artigo |
| Sprog: | engelsk |
| Udgivet: |
2008
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| Online adgang: | https://doi.org/10.1002/anie.200704594 |
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