Copper inhibits <i>β</i>-amyloid production and stimulates the non-amyloidogenic pathway of amyloid-precursor-protein secretion
Previous studies have demonstrated that amyloid precursor protein (APP) can bind and reduce Cu(II) to Cu(I), leading to oxidative modification of APP. In the present study we show that adding copper to Chinese-hamster ovary (CHO) cells greatly reduced the levels of amyloid Abeta peptide (Abeta) both...
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| Main Authors: | , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
1999
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| Online Access: | https://doi.org/10.1042/bj3440461 |
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