Alkaline Phosphatase Knock-Out Mice Recapitulate the Metabolic and Skeletal Defects of Infantile Hypophosphatasia
Abstract Hypophosphatasia is an inborn error of metabolism characterized by deficient activity of the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP) and skeletal disease due to impaired mineralization of cartilage and bone matrix. We investigated two independently generated TNSALP gen...
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| Main Authors: | , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | inglés |
| Publicado: |
1999
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| Acceso en liña: | https://doi.org/10.1359/jbmr.1999.14.12.2015 |
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