Alkaline Phosphatase Knock-Out Mice Recapitulate the Metabolic and Skeletal Defects of Infantile Hypophosphatasia

Alkaline Phosphatase Knock-Out Mice Recapitulate the Metabolic and Skeletal Defects of Infantile Hypophosphatasia

Abstract Hypophosphatasia is an inborn error of metabolism characterized by deficient activity of the tissue-nonspecific isoenzyme of alkaline phosphatase (TNSALP) and skeletal disease due to impaired mineralization of cartilage and bone matrix. We investigated two independently generated TNSALP gen...

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Detalles Bibliográficos
Main Authors:	K N Fedde, Libby A. Blair, Julie Silverstein, Stephen P. Coburn, Lawrence M. Ryan, Robert S. Weinstein, Katrina G. Waymire, Sonoko Narisawa, José Luís Millán, Grant R. MacGregor, Michael P. Whyte
Formato:	Artigo
Idioma:	inglés
Publicado:	1999
Acceso en liña:	https://doi.org/10.1359/jbmr.1999.14.12.2015
Tags:	Engadir etiqueta Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

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