7 beta-hydroperoxycholest-5-en-3 beta-ol, a component of human atherosclerotic lesions, is the primary cytotoxin of oxidized human low density lipoprotein.
Modification of low density lipoprotein (LDL) by free radical oxidation renders this molecular complex cytotoxic. Oxidized lipoproteins exist in vivo in atherosclerotic lesions and in the plasma of diabetic animals, suggesting that lipoprotein-induced tissue damage may occur in certain diseases. We...
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| Autors principals: | , , , , , , , |
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| Format: | Artigo |
| Idioma: | anglès |
| Publicat: |
1994
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| Accés en línia: | https://doi.org/10.1073/pnas.91.24.11452 |
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