BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice

Current therapy for patients with hereditary absence of cochlear hair cells, who have severe or profound deafness, is restricted to cochlear implantation, a procedure that requires survival of the auditory nerve. Mouse mutations that serve as models for genetic deafness can be utilized for developin...

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Bibliographic Details
Main Authors: H. Fukui, Hiu-Tung Wong, Lisa A. Beyer, Ben Case, Donald L. Swiderski, Adriana Di Polo, Allen F. Ryan, Yehoash Raphael
Format: Artigo
Language:English
Published: 2012
Online Access:https://doi.org/10.1038/srep00838
https://www.nature.com/articles/srep00838.pdf
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