BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice

Current therapy for patients with hereditary absence of cochlear hair cells, who have severe or profound deafness, is restricted to cochlear implantation, a procedure that requires survival of the auditory nerve. Mouse mutations that serve as models for genetic deafness can be utilized for developin...

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Autors principals: H. Fukui, Hiu-Tung Wong, Lisa A. Beyer, Ben Case, Donald L. Swiderski, Adriana Di Polo, Allen F. Ryan, Yehoash Raphael
Format: Artigo
Idioma:anglès
Publicat: 2012
Accés en línia:https://doi.org/10.1038/srep00838
https://www.nature.com/articles/srep00838.pdf
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