BDNF gene therapy induces auditory nerve survival and fiber sprouting in deaf Pou4f3 mutant mice

Current therapy for patients with hereditary absence of cochlear hair cells, who have severe or profound deafness, is restricted to cochlear implantation, a procedure that requires survival of the auditory nerve. Mouse mutations that serve as models for genetic deafness can be utilized for developin...

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Main Authors: H. Fukui, Hiu-Tung Wong, Lisa A. Beyer, Ben Case, Donald L. Swiderski, Adriana Di Polo, Allen F. Ryan, Yehoash Raphael
格式: Artigo
语言:英语
出版: 2012
在线阅读:https://doi.org/10.1038/srep00838
https://www.nature.com/articles/srep00838.pdf
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