The RAF inhibitor PLX4032 inhibits ERK signaling and tumor cell proliferation in a V600E BRAF-selective manner
Tumors with mutant BRAF and some with mutant RAS are dependent upon ERK signaling for proliferation, and their growth is suppressed by MAPK/ERK kinase (MEK) inhibitors. In contrast, tumor cells with human EGF receptor (HER) kinase activation proliferate in a MEK-independent manner. These findings ha...
Guardat en:
| Autors principals: | , , , , , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | anglès |
| Publicat: |
2010
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| Accés en línia: | https://doi.org/10.1073/pnas.1008990107 |
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