Immunodominance of HLA-A2-Restricted Hepatitis C Virus-Specific CD8 <sup>+</sup> T Cell Responses Is Linked to Naïve-Precursor Frequency

ABSTRACT The impact of naïve-precursor frequency on human virus-specific CD8 + T cell immunodominance is not well understood. Using a recently developed major histocompatibility complex (MHC) class I tetramer enrichment protocol, we found a conserved hierarchy and a &gt;10-fold difference in naï...

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Main Authors: Julia Schmidt, Christoph Neumann‐Haefelin, Tayibe Altay, Emma Gostick, David A. Price, Volker Lohmann, Hubert E. Blum, Robert Thimme
格式: Artigo
语言:英语
出版: 2011
在线阅读:https://doi.org/10.1128/jvi.00093-11
https://jvi.asm.org/content/jvi/85/10/5232.full.pdf
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