Immunodominance of HLA-A2-Restricted Hepatitis C Virus-Specific CD8 <sup>+</sup> T Cell Responses Is Linked to Naïve-Precursor Frequency
ABSTRACT The impact of naïve-precursor frequency on human virus-specific CD8 + T cell immunodominance is not well understood. Using a recently developed major histocompatibility complex (MHC) class I tetramer enrichment protocol, we found a conserved hierarchy and a >10-fold difference in naï...
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| Main Authors: | , , , , , , , |
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| Format: | Artigo |
| Language: | English |
| Published: |
2011
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| Online Access: | https://doi.org/10.1128/jvi.00093-11 https://jvi.asm.org/content/jvi/85/10/5232.full.pdf |
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