Genotype‐directed, dose‐finding study of irinotecan in cancer patients with <i>UGT1A1*28</i> and/or <i>UGT1A1*6</i> polymorphisms

Genotype‐directed, dose‐finding study of irinotecan in cancer patients with <i>UGT1A1*28</i> and/or <i>UGT1A1*6</i> polymorphisms

Irinotecan-induced severe neutropenia is associated with homozygosity for the UGT1A1*28 or UGT1A1*6 alleles. In this study, we determined the maximum-tolerated dose (MTD) of irinotecan in patients with UGT1A1 polymorphisms. Patients who had received chemotherapy other than irinotecan for metastatic...

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Main Authors: Taroh Satoh, Takashi Ura, Yasuhide Yamada, Kentaro Yamazaki, Toshimasa Tsujinaka, Masaki Munakata, Tomohiro Nishina, Shu Okamura, Taito Esaki, Yasutsuna Sasaki, Wasaburo Koizumi, Yoshihiro Kakeji, Naoki Ishizuka, Ichinosuke Hyodo, Yuh Sakata
格式: Artigo
语言:英语
出版: 2011
在线阅读:https://doi.org/10.1111/j.1349-7006.2011.02030.x
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.2011.02030.x
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https://doi.org/10.1111/j.1349-7006.2011.02030.x
https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1349-7006.2011.02030.x

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