Binding of the Second Generation Non-nucleoside Inhibitor S-1153 to HIV-1 Reverse Transcriptase Involves Extensive Main Chain Hydrogen Bonding
S-1153 (AG1549) is perhaps the most promising non-nucleoside inhibitor of HIV-1 reverse transcriptase currently under development as a potential anti-AIDS drug, because it has a favorable profile of resilience to many drug resistance mutations. We have determined the crystal structure of S-1153 in a...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | 英语 |
| 出版: |
2000
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| 在線閱讀: | https://doi.org/10.1074/jbc.275.19.14316 http://www.jbc.org/article/S0021925819806026/pdf |
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