An Engineered Human IgG1 Antibody with Longer Serum Half-Life
The serum half-life of IgG Abs is regulated by the neonatal Fc receptor (FcRn). By binding to FcRn in endosomes, IgG Abs are salvaged from lysosomal degradation and recycled to the circulation. Several studies have demonstrated a correlation between the binding affinity of IgG Abs to FcRn and their...
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| Main Authors: | , , , , , |
|---|---|
| 格式: | Artigo |
| 语言: | 英语 |
| 出版: |
2006
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| 在线阅读: | https://doi.org/10.4049/jimmunol.176.1.346 https://www.jimmunol.org/content/jimmunol/176/1/346.full.pdf |
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