Targeted Delivery of Mycobacterial Antigens to Human Dendritic Cells via Siglec-7 Induces Robust T Cell Activation
Lipids from mycobacteria can be presented to human T cells by group 1 CD1 Ag-presenting molecules (CD1a, CD1b, and CD1c). Group 1 CD1-restricted T cells are activated by lipid Ags presented by myeloid dendritic cells (DCs), after which they generate antibacterial effector functions, including IFN-γ...
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| Main Authors: | , , , , , , |
|---|---|
| Format: | Artigo |
| Language: | English |
| Published: |
2014
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| Online Access: | https://doi.org/10.4049/jimmunol.1303278 |
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