Targeted Delivery of Mycobacterial Antigens to Human Dendritic Cells via Siglec-7 Induces Robust T Cell Activation

Targeted Delivery of Mycobacterial Antigens to Human Dendritic Cells via Siglec-7 Induces Robust T Cell Activation

Lipids from mycobacteria can be presented to human T cells by group 1 CD1 Ag-presenting molecules (CD1a, CD1b, and CD1c). Group 1 CD1-restricted T cells are activated by lipid Ags presented by myeloid dendritic cells (DCs), after which they generate antibacterial effector functions, including IFN-γ...

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Hauptverfasser:	Norihito Kawasaki, Cory D. Rillahan, Tan‐Yun Cheng, Ildiko Van Rhijn, Matthew S. Macauley, D. Branch Moody, James C. Paulson
Format:	Artigo
Sprache:	Englisch
Veröffentlicht:	2014
Online-Zugang:	https://doi.org/10.4049/jimmunol.1303278
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

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